Chemical Protein Synthesis

Chemical Protein Synthesis (CPS)

• We synthesize peptide fragments that are then “stitched” together to give the full length linear protein

• The linear polypeptide is then folded into the protein

• Recombinant protein synthesis is restricted to the 20 known amino acids.

• CPS has no such restrictions

• Using CPS we can add in virtually any post translation modification, non-natural amino acids, PEGs, lipids and in any position in the amino acid sequence